This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for SRPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:35,687,984–35,689,594 | 232.1 kb | Distal (>10kb) Multiome | 968 | |
| chr6:35,727,435–35,728,457 | 193.2 kb | Distal (>10kb) Multiome | 812 | |
| chr6:35,731,025–35,732,630 | 189.4 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:35,764,004–35,765,052 | 156.6 kb | Distal (>10kb) Multiome | 254 | |
| chr6:35,776,412–35,776,992 | 144.5 kb | Distal (>10kb) Multiome | 410 | |
| chr6:35,804,967–35,805,624 | 115.9 kb | Distal (>10kb) Multiome | 815 | |
| chr6:35,920,112–35,921,529 | 31 bp | At TSS Multiome | 965 | |
| chr6:35,931,065–35,931,702 | 10.2 kb | Distal (>10kb) Multiome | 77 | |
| chr6:36,027,295–36,028,609 | 106.6 kb | Distal (>10kb) Multiome | 1031 | |
| chr6:36,130,184–36,131,324 | 209.4 kb | Distal (>10kb) Multiome | 615 | |
| chr6:36,196,013–36,197,672 | 275.4 kb | Distal (>10kb) Multiome | 825 |
Genomic view of the SRPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.