The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRPA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRPA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRPA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:71,843,237–71,844,888 | 231.5 kb | Distal (>10kb) Multiome | 479 | |
| chr8:72,004,121–72,005,732 | 70.3 kb | Distal (>10kb) Multiome | 364 | |
| chr8:72,040,280–72,041,455 | 34.9 kb | Distal (>10kb) Multiome | 108 | |
| chr8:72,075,016–72,075,959 | 8 bp | At TSS Multiome | 217 | |
| chr8:72,134,114–72,134,981 | 58.9 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the TRPA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.