The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for INSIG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INSIG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INSIG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:117,814,354–117,815,236 | 273.9 kb | Distal (>10kb) Multiome | 987 | |
| chr2:117,835,820–117,836,917 | 252.4 kb | Distal (>10kb) Multiome | 337 | |
| chr2:117,849,927–117,850,957 | 238.1 kb | Distal (>10kb) Multiome | 288 | |
| chr2:117,851,735–117,852,372 | 236.4 kb | Distal (>10kb) Multiome | 96 | |
| chr2:117,853,013–117,853,974 | 235.1 kb | Distal (>10kb) Multiome | 109 | |
| chr2:117,854,448–117,855,028 | 233.7 kb | Distal (>10kb) Multiome | 71 | |
| chr2:118,013,165–118,014,769 | 74.5 kb | Distal (>10kb) Multiome | 833 | |
| chr2:118,087,899–118,089,495 | 191 bp | At TSS Multiome | 907 | |
| chr2:118,185,218–118,186,863 | 97.9 kb | Distal (>10kb) Multiome | 532 | |
| chr2:118,224,106–118,225,489 | 135.9 kb | Distal (>10kb) Multiome | 219 | |
| chr2:118,255,734–118,256,893 | 167.9 kb | Distal (>10kb) Multiome | 49 | |
| chr2:118,309,731–118,310,680 | 221.5 kb | Distal (>10kb) Multiome | 280 | |
| chr2:118,310,862–118,311,497 | 222.6 kb | Distal (>10kb) Multiome | 111 | |
| chr2:118,319,218–118,319,735 | 230.9 kb | Distal (>10kb) Multiome | 187 | |
| chr2:118,855,419–118,856,205 | 767.3 kb | Distal (>10kb) Multiome HiCAR | 527 |
Genomic view of the INSIG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.