Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for RXRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RXRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RXRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:134,067,300–134,068,908 | 258.2 kb | Distal (>10kb) Multiome | 721 | |
| chr9:134,135,166–134,136,822 | 190.5 kb | Distal (>10kb) Multiome | 790 | |
| chr9:134,325,382–134,326,571 | 238 bp | At TSS Multiome | 544 | |
| chr9:134,328,402–134,328,794 | 1.9 kb | Proximal (<10kb) | 371 | |
| chr9:134,443,063–134,443,607 | 117.0 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr9:134,590,783–134,591,420 | 264.6 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the RXRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.