This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNX27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,327,019–151,328,343 | 284.6 kb | Distal (>10kb) Multiome | 719 | |
| chr1:151,346,796–151,347,793 | 264.9 kb | Distal (>10kb) Multiome | 711 | |
| chr1:151,399,359–151,400,043 | 212.7 kb | Distal (>10kb) Multiome | 776 | |
| chr1:151,458,247–151,459,879 | 152.8 kb | Distal (>10kb) Multiome | 796 | |
| chr1:151,491,747–151,492,512 | 120.0 kb | Distal (>10kb) Multiome | 146 | |
| chr1:151,502,459–151,503,303 | 109.3 kb | Distal (>10kb) Multiome | 99 | |
| chr1:151,510,863–151,512,136 | 100.8 kb | Distal (>10kb) Multiome | 640 | |
| chr1:151,539,661–151,541,320 | 71.9 kb | Distal (>10kb) Multiome | 830 | |
| chr1:151,611,789–151,613,070 | 112 bp | At TSS Multiome | 761 | |
| chr1:151,721,370–151,721,843 | 109.4 kb | Distal (>10kb) Multiome | 186 | |
| chr1:151,762,987–151,763,859 | 151.3 kb | Distal (>10kb) Multiome | 848 | |
| chr1:151,790,055–151,791,612 | 178.4 kb | Distal (>10kb) Multiome | 953 | |
| chr1:151,839,238–151,840,386 | 227.6 kb | Distal (>10kb) Multiome | 493 | |
| chr1:151,909,150–151,910,123 | 297.4 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the SNX27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.