This 21-gene module includes PPARA, TRPA1, LPIN1, BNIP3L, and ARID3A, with enriched terms related to lipid metabolism, fatty acid oxidation, and autophagy. Knockdown of SOX17, EOMESODERMIN, and GATA6 activates this module. Knockdown of NANOG, OCT4, and SOX2 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.