This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for POLH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,285,054–43,285,508 | 290.8 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 267.4 kb | Distal (>10kb) Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 206.5 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 148.5 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 121.5 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 98.6 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 69.3 kb | Distal (>10kb) Multiome | 474 | |
| chr6:43,509,337–43,511,016 | 65.8 kb | Distal (>10kb) Multiome | 734 | |
| chr6:43,516,463–43,517,515 | 59.2 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 121 bp | At TSS Multiome | 1044 | |
| chr6:43,628,488–43,630,447 | 54.0 kb | Distal (>10kb) Multiome | 1157 | |
| chr6:43,635,496–43,636,104 | 59.6 kb | Distal (>10kb) Multiome | 941 | |
| chr6:43,644,712–43,645,902 | 69.2 kb | Distal (>10kb) Multiome | 255 | |
| chr6:43,667,273–43,667,900 | 91.2 kb | Distal (>10kb) Multiome | 625 | |
| chr6:43,667,997–43,668,873 | 92.3 kb | Distal (>10kb) Multiome | 664 | |
| chr6:43,695,239–43,695,940 | 119.5 kb | Distal (>10kb) Multiome | 207 | |
| chr6:43,702,335–43,703,403 | 126.8 kb | Distal (>10kb) Multiome | 713 | |
| chr6:43,706,840–43,708,370 | 131.8 kb | Distal (>10kb) Multiome | 307 | |
| chr6:43,739,421–43,740,065 | 163.6 kb | Distal (>10kb) Multiome | 175 | |
| chr6:43,769,188–43,772,162 | 193.8 kb | Distal (>10kb) Multiome | 1112 | |
| chr6:43,774,651–43,775,250 | 198.8 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the POLH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.