This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for LUC7L3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LUC7L3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LUC7L3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,425,595–50,426,626 | 293.4 kb | Distal (>10kb) Multiome | 619 | |
| chr17:50,478,411–50,479,262 | 240.7 kb | Distal (>10kb) Multiome | 956 | |
| chr17:50,508,047–50,508,856 | 211.1 kb | Distal (>10kb) Multiome | 332 | |
| chr17:50,541,672–50,542,697 | 177.4 kb | Distal (>10kb) Multiome | 772 | |
| chr17:50,546,778–50,547,615 | 172.4 kb | Distal (>10kb) Multiome | 786 | |
| chr17:50,558,590–50,561,781 | 159.1 kb | Distal (>10kb) Multiome | 587 | |
| chr17:50,586,525–50,587,142 | 132.8 kb | Distal (>10kb) Multiome | 43 | |
| chr17:50,634,652–50,635,325 | 84.6 kb | Distal (>10kb) Multiome | 471 | |
| chr17:50,707,179–50,708,006 | 11.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr17:50,719,167–50,720,018 | 3 bp | At TSS Multiome | 1050 | |
| chr17:50,753,496–50,753,712 | 9.8 kb | Proximal (<10kb) | 15 | |
| chr17:50,865,239–50,868,097 | 146.9 kb | Distal (>10kb) Multiome | 1256 | |
| chr17:50,905,047–50,905,768 | 186.0 kb | Distal (>10kb) Multiome | 556 | |
| chr17:50,931,004–50,931,866 | 211.7 kb | Distal (>10kb) Multiome | 780 | |
| chr17:50,944,102–50,945,190 | 225.0 kb | Distal (>10kb) Multiome | 985 | |
| chr17:50,950,043–50,950,638 | 230.9 kb | Distal (>10kb) Multiome | 713 |
Genomic view of the LUC7L3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.