Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KCTD20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:36,196,013–36,197,672 | 246.5 kb | Distal (>10kb) Multiome | 825 | |
| chr6:36,284,908–36,285,433 | 157.8 kb | Distal (>10kb) Multiome | 104 | |
| chr6:36,360,373–36,360,968 | 82.3 kb | Distal (>10kb) Multiome | 348 | |
| chr6:36,368,910–36,369,452 | 73.8 kb | Distal (>10kb) Multiome | 68 | |
| chr6:36,387,482–36,388,139 | 55.1 kb | Distal (>10kb) Multiome | 262 | |
| chr6:36,423,143–36,423,810 | 19.6 kb | Distal (>10kb) Multiome | 886 | |
| chr6:36,441,466–36,441,710 | 1.3 kb | Proximal (<10kb) | 591 | |
| chr6:36,442,626–36,443,451 | 21 bp | At TSS Multiome | 982 | |
| chr6:36,546,941–36,548,024 | 104.5 kb | Distal (>10kb) Multiome | 887 | |
| chr6:36,593,473–36,594,773 | 151.3 kb | Distal (>10kb) Multiome | 1156 | |
| chr6:36,650,865–36,651,585 | 208.2 kb | Distal (>10kb) Multiome | 207 | |
| chr6:36,678,325–36,679,788 | 235.7 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the KCTD20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.