Involved in ribosomal large subunit biogenesis and translational initiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LTO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LTO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LTO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:68,840,765–68,842,245 | 833.4 kb | Distal (>10kb) Multiome HiCAR | 567 | |
| chr11:68,843,712–68,844,382 | 831.3 kb | Distal (>10kb) Multiome HiCAR | 675 | |
| chr11:69,122,768–69,123,396 | 552.4 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr11:69,442,945–69,443,770 | 231.8 kb | Distal (>10kb) Multiome | 754 | |
| chr11:69,636,341–69,637,110 | 38.7 kb | Distal (>10kb) Multiome | 292 | |
| chr11:69,637,726–69,639,648 | 37.2 kb | Distal (>10kb) Multiome | 644 | |
| chr11:69,640,489–69,642,473 | 34.2 kb | Distal (>10kb) Multiome | 770 | |
| chr11:69,642,597–69,643,808 | 31.9 kb | Distal (>10kb) Multiome | 599 | |
| chr11:69,670,294–69,670,532 | 4.8 kb | Proximal (<10kb) | 426 | |
| chr11:69,674,751–69,675,727 | 52 bp | At TSS Multiome | 862 | |
| chr11:69,700,636–69,701,130 | 25.5 kb | Distal (>10kb) Multiome | 508 | |
| chr11:69,703,191–69,705,251 | 29.4 kb | Distal (>10kb) Multiome | 446 | |
| chr11:69,773,877–69,776,365 | 100.1 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the LTO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.