The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MFN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:179,071,152–179,072,483 | 275.9 kb | Distal (>10kb) Multiome | 794 | |
| chr3:179,147,033–179,149,466 | 199.5 kb | Distal (>10kb) Multiome | 953 | |
| chr3:179,260,956–179,261,810 | 86.3 kb | Distal (>10kb) Multiome | 616 | |
| chr3:179,322,380–179,323,876 | 24.8 kb | Distal (>10kb) Multiome | 958 | |
| chr3:179,346,338–179,348,224 | 96 bp | At TSS Multiome | 843 | |
| chr3:179,450,888–179,452,034 | 103.8 kb | Distal (>10kb) Multiome | 580 | |
| chr3:179,504,159–179,505,204 | 156.9 kb | Distal (>10kb) Multiome | 128 | |
| chr3:179,526,783–179,527,418 | 179.4 kb | Distal (>10kb) Multiome | 358 | |
| chr3:179,562,395–179,564,138 | 215.1 kb | Distal (>10kb) Multiome HiCAR | 866 | |
| chr3:179,604,200–179,605,304 | 257.0 kb | Distal (>10kb) Multiome | 786 | |
| chr3:179,608,248–179,609,637 | 261.1 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the MFN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.