HEXIM1

HEXIM P-TEFb complex subunit 1 | CLP-1, EDG1, HIS1, MAQ1

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

Member of: DE-5 DE-5.10

Biological processes 28 terms

7SK snRNA binding (GO:0097322)7SK snRNA binding (GO:0097322)7SK snRNP (GO:0120259)P-TEFb complex binding (GO:0106140)activation of innate immune response (GO:0002218)cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861)cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861)cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)identical protein binding (GO:0042802)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription elongation by RNA polymerase II (GO:0034244)negative regulation of transcription elongation by RNA polymerase II (GO:0034244)negative regulation of viral transcription (GO:0032897)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of signal transduction by p53 class mediator (GO:1901798)protein binding (GO:0005515)protein kinase inhibitor activity (GO:0004860)snRNA binding (GO:0017069)snRNA binding (GO:0017069)transcription regulator inhibitor activity (GO:0140416)

Expression (TPM)

TFs regulating HEXIM1 0 TFs

Transcription factors with Perturb-seq knockdown data for HEXIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEXIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HEXIM1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEXIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:44,899,009–44,900,053	248.8 kb	Distal (>10kb) Multiome	987
chr17:44,911,165–44,911,786	237.0 kb	Distal (>10kb) Multiome	412
chr17:44,947,322–44,948,161	200.7 kb	Distal (>10kb) Multiome	891
chr17:44,966,864–44,969,160	180.0 kb	Distal (>10kb) Multiome	526
chr17:44,987,181–44,987,616	160.9 kb	Distal (>10kb) Multiome	93
chr17:45,021,768–45,022,248	126.4 kb	Distal (>10kb) Multiome	739
chr17:45,051,210–45,051,755	96.9 kb	Distal (>10kb) Multiome	771
chr17:45,060,587–45,061,694	87.2 kb	Distal (>10kb) Multiome	979
chr17:45,131,590–45,133,655	15.1 kb	Distal (>10kb) Multiome	898
chr17:45,135,189–45,136,052	12.9 kb	Distal (>10kb) Multiome	930
chr17:45,143,207–45,145,183	4.6 kb	Proximal (<10kb) Multiome	308
chr17:45,147,066–45,150,271	1.1 kb	Proximal (<10kb) Multiome	1345
chr17:45,160,688–45,162,340	13.2 kb	Distal (>10kb) Multiome	1200
chr17:45,197,493–45,198,189	49.5 kb	Distal (>10kb) Multiome HiCAR	835
chr17:45,241,380–45,242,217	93.4 kb	Distal (>10kb) Multiome	131
chr17:45,246,828–45,248,615	99.3 kb	Distal (>10kb) Multiome	858
chr17:45,261,690–45,262,406	113.6 kb	Distal (>10kb) Multiome	234
chr17:45,316,202–45,317,910	168.7 kb	Distal (>10kb) Multiome	857
chr17:45,334,174–45,334,847	185.9 kb	Distal (>10kb) Multiome	149
chr17:45,371,481–45,372,140	223.4 kb	Distal (>10kb) Multiome	704
chr17:45,395,009–45,395,645	246.8 kb	Distal (>10kb) Multiome	482
chr17:45,404,953–45,406,129	257.0 kb	Distal (>10kb) Multiome	244
chr17:45,425,403–45,426,061	277.3 kb	Distal (>10kb) Multiome	506
chr17:45,427,967–45,428,575	279.8 kb	Distal (>10kb) Multiome	454
chr17:45,429,511–45,430,237	281.3 kb	Distal (>10kb) Multiome	190
chr17:45,431,253–45,432,633	283.3 kb	Distal (>10kb) Multiome	435

Genome Browser

Genomic view of the HEXIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.