Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GNB5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNB5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNB5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,971,175–51,972,397 | 208.1 kb | Distal (>10kb) Multiome | 887 | |
| chr15:52,008,542–52,009,373 | 171.0 kb | Distal (>10kb) Multiome | 499 | |
| chr15:52,018,740–52,020,253 | 160.7 kb | Distal (>10kb) Multiome | 1045 | |
| chr15:52,111,990–52,112,768 | 67.6 kb | Distal (>10kb) Multiome | 189 | |
| chr15:52,139,658–52,140,475 | 40.0 kb | Distal (>10kb) Multiome | 400 | |
| chr15:52,179,295–52,180,708 | 238 bp | At TSS Multiome | 715 | |
| chr15:52,183,677–52,183,850 | 3.7 kb | Proximal (<10kb) | 58 | |
| chr15:52,261,434–52,262,154 | 81.9 kb | Distal (>10kb) Multiome | 313 | |
| chr15:52,294,913–52,296,036 | 115.8 kb | Distal (>10kb) Multiome | 630 | |
| chr15:52,392,159–52,392,836 | 212.5 kb | Distal (>10kb) Multiome | 167 |
Genomic view of the GNB5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.