The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for WWC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WWC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WWC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:168,007,105–168,007,570 | 284.5 kb | Distal (>10kb) Multiome | 56 | |
| chr5:168,047,104–168,048,497 | 243.7 kb | Distal (>10kb) Multiome | 384 | |
| chr5:168,177,772–168,178,816 | 113.4 kb | Distal (>10kb) Multiome | 157 | |
| chr5:168,268,702–168,269,867 | 22.1 kb | Distal (>10kb) Multiome | 609 | |
| chr5:168,282,290–168,282,469 | 9.2 kb | Proximal (<10kb) | 216 | |
| chr5:168,286,402–168,286,777 | 4.9 kb | Proximal (<10kb) | 53 | |
| chr5:168,291,138–168,293,102 | 6 bp | At TSS Multiome | 633 | |
| chr5:168,295,589–168,296,149 | 4.2 kb | Proximal (<10kb) Multiome | 209 | |
| chr5:168,328,780–168,329,633 | 37.5 kb | Distal (>10kb) Multiome | 243 | |
| chr5:168,334,311–168,335,028 | 43.2 kb | Distal (>10kb) Multiome HiCAR | 189 | |
| chr5:168,486,057–168,486,891 | 194.8 kb | Distal (>10kb) Multiome | 846 | |
| chr5:168,528,975–168,529,622 | 237.6 kb | Distal (>10kb) Multiome | 229 | |
| chr5:168,578,780–168,580,390 | 288.0 kb | Distal (>10kb) Multiome | 938 | |
| chr5:168,580,861–168,581,396 | 289.5 kb | Distal (>10kb) Multiome | 158 |
Genomic view of the WWC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.