This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADAMTS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:26,572,374–26,573,592 | 270.0 kb | Distal (>10kb) Multiome | 218 | |
| chr21:26,842,972–26,847,283 | 331 bp | At TSS Multiome | 698 | |
| chr21:26,850,129–26,850,502 | 4.7 kb | Proximal (<10kb) | 97 | |
| chr21:26,853,121–26,853,311 | 7.7 kb | Proximal (<10kb) | 12 | |
| chr21:26,856,178–26,856,869 | 13.4 kb | Distal (>10kb) Multiome | 107 | |
| chr21:26,965,256–26,966,609 | 122.6 kb | Distal (>10kb) Multiome | 302 | |
| chr21:27,025,101–27,026,890 | 183.0 kb | Distal (>10kb) Multiome | 212 | |
| chr21:28,516,848–28,517,501 | 1674.1 kb | Distal (>10kb) Multiome HiCAR | 284 |
Genomic view of the ADAMTS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.