MED1
mediator complex subunit 1 | CRSP1, CRSP200, DRIP230, PBP, RB18A, TRAP220, PPARBP, PPARGBP, TRIP2

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Member of: DE-5 DE-5.21
Biological processes 102 terms
DNA binding (GO:0003677)DNA-binding transcription factor binding (GO:0140297)LBD domain binding (GO:0050693)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II preinitiation complex assembly (GO:0051123)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)androgen biosynthetic process (GO:0006702)angiogenesis (GO:0001525)angiogenesis (GO:0001525)cell morphogenesis (GO:0000902)cellular response to epidermal growth factor stimulus (GO:0071364)cellular response to steroid hormone stimulus (GO:0071383)cellular response to thyroid hormone stimulus (GO:0097067)cellular response to thyroid hormone stimulus (GO:0097067)cellular response to thyroid hormone stimulus (GO:0097067)chromatin (GO:0000785)chromatin DNA binding (GO:0031490)chromatin binding (GO:0003682)chromatin binding (GO:0003682)erythrocyte development (GO:0048821)erythrocyte development (GO:0048821)fat cell differentiation (GO:0045444)general transcription initiation factor binding (GO:0140296)histone acetyltransferase binding (GO:0035035)keratinocyte differentiation (GO:0030216)lens development in camera-type eye (GO:0002088)lens development in camera-type eye (GO:0002088)mRNA transcription by RNA polymerase II (GO:0042789)mRNA transcription by RNA polymerase II (GO:0042789)mediator complex (GO:0016592)mediator complex (GO:0016592)mediator complex (GO:0016592)mediator complex (GO:0016592)megakaryocyte development (GO:0035855)megakaryocyte development (GO:0035855)membrane (GO:0016020)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of keratinocyte proliferation (GO:0010839)negative regulation of neuron differentiation (GO:0045665)negative regulation of neuron differentiation (GO:0045665)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear estrogen receptor binding (GO:0030331)nuclear receptor binding (GO:0016922)nuclear receptor binding (GO:0016922)nuclear receptor binding (GO:0016922)nuclear receptor-mediated steroid hormone signaling pathway (GO:0030518)nuclear retinoic acid receptor binding (GO:0042974)nuclear retinoic acid receptor binding (GO:0042974)nuclear thyroid hormone receptor binding (GO:0046966)nuclear thyroid hormone receptor binding (GO:0046966)nuclear thyroid hormone receptor binding (GO:0046966)nuclear thyroid hormone receptor binding (GO:0046966)nuclear vitamin D receptor binding (GO:0042809)nuclear vitamin D receptor binding (GO:0042809)nuclear vitamin D receptor binding (GO:0042809)nuclear vitamin D receptor binding (GO:0042809)nuclear vitamin D receptor binding (GO:0042809)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peroxisome proliferator activated receptor binding (GO:0042975)peroxisome proliferator activated receptor binding (GO:0042975)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of erythrocyte differentiation (GO:0045648)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of keratinocyte differentiation (GO:0045618)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)promoter-specific chromatin binding (GO:1990841)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein-DNA complex (GO:0032993)protein-containing complex binding (GO:0044877)regulation of RNA biosynthetic process (GO:2001141)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)retinal pigment epithelium development (GO:0003406)thyroid hormone receptor signaling pathway (GO:0002154)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription coactivator binding (GO:0001223)transcription coregulator activity (GO:0003712)transcription coregulator activity (GO:0003712)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)ubiquitin ligase complex (GO:0000151)ubiquitin protein ligase activity (GO:0061630)ventricular trabecula myocardium morphogenesis (GO:0003222)
Expression (TPM)
MED1 — as a Regulated Gene

TFs regulating MED1 0 TFs

Transcription factors with Perturb-seq knockdown data for MED1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MED1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:39,152,575–39,154,848 296.8 kb Distal (>10kb) Multiome 1041
chr17:39,164,617–39,165,311 286.3 kb Distal (>10kb) Multiome 371
chr17:39,197,170–39,198,193 253.6 kb Distal (>10kb) Multiome 515
chr17:39,199,726–39,200,760 251.1 kb Distal (>10kb) Multiome 947
chr17:39,209,452–39,209,995 241.4 kb Distal (>10kb) Multiome 268
chr17:39,225,532–39,226,262 225.3 kb Distal (>10kb) Multiome 235
chr17:39,244,638–39,245,241 206.4 kb Distal (>10kb) Multiome 348
chr17:39,400,997–39,402,766 48.7 kb Distal (>10kb) Multiome 898
chr17:39,450,919–39,451,504 48 bp At TSS Multiome 722
chr17:39,461,043–39,462,217 10.2 kb Distal (>10kb) Multiome 1026
chr17:39,573,453–39,574,243 122.5 kb Distal (>10kb) Multiome 520
chr17:39,636,769–39,637,600 185.9 kb Distal (>10kb) Multiome 853
chr17:39,652,588–39,653,348 201.7 kb Distal (>10kb) Multiome 263
chr17:39,668,234–39,668,690 217.3 kb Distal (>10kb) Multiome 706
chr17:39,687,710–39,688,437 236.7 kb Distal (>10kb) Multiome 800
chr17:39,695,905–39,696,636 245.0 kb Distal (>10kb) Multiome 499
chr17:39,699,516–39,700,527 248.7 kb Distal (>10kb) Multiome 528
chr17:39,730,039–39,730,906 279.2 kb Distal (>10kb) Multiome 886
chr17:39,739,067–39,739,915 288.2 kb Distal (>10kb) Multiome 648
chr17:39,740,384–39,740,910 289.5 kb Distal (>10kb) Multiome 513

Genome Browser

Genomic view of the MED1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:39,142,575 – 39,750,910
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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