Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PTGR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTGR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTGR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:75,203,842–75,205,949 | 4.7 kb | Proximal (<10kb) Multiome | 272 | |
| chr18:75,206,774–75,206,965 | 2.2 kb | Proximal (<10kb) | 61 | |
| chr18:75,207,940–75,210,115 | 206 bp | At TSS Multiome | 742 | |
| chr18:75,211,089–75,212,360 | 1.9 kb | Proximal (<10kb) | 453 | |
| chr18:75,455,125–75,456,221 | 246.5 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the PTGR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.