This 12-gene module includes CARD8, SS18, CDR2, ZFAND6, and FEZ2, with enrichment in apoptosis, protein ubiquitination, and proteasomal degradation pathways. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN and FOXA2 represses it.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.