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DE-5.8

Submodule 18 genes

mRNA metabolism and mitochondrial protein quality control

This 18-gene module includes CHUK, MFN2, LONP1, SETD1A, and SART3, with enrichment in mRNA metabolic process. No transcription factor knockdown data are available for this module, limiting inference of regulatory control during ESC-to-DE differentiation.

Key terms: spliceosomal snRNP assembly RNA processing nucleobase-containing compound metabolic process spliceosomal tri-snRNP complex assembly Notable genes: CHUK MFN2 LONP1 SETD1A MBD3 SART3 PRRC2A PRPF3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (18)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z
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