DE-5

DE-5.9

Submodule 17 genes

Metabolic and protein modification pathways

This module contains 17 genes including MTRR, SOAT1, OTULIN, SPSB1, and MSL1, involved in metabolic processes and protein modification. Knockdown of ZC3H3 represses this module, suggesting it normally supports these metabolic functions.

Notable genes: MTRR SOAT1 OTULIN SPSB1 EFS MSL1 ZYG11A DIS3L Top TFs: ZC3H3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (17)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z