This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for DNAAF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAAF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAAF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:55,288,999–55,291,001 | 207.9 kb | Distal (>10kb) Multiome | 744 | |
| chr15:55,318,855–55,319,494 | 179.2 kb | Distal (>10kb) Multiome | 875 | |
| chr15:55,394,084–55,395,667 | 103.4 kb | Distal (>10kb) Multiome | 153 | |
| chr15:55,407,568–55,409,007 | 90.0 kb | Distal (>10kb) Multiome | 957 | |
| chr15:55,498,088–55,498,593 | 61 bp | At TSS Multiome | 637 | |
| chr15:55,587,537–55,588,889 | 90.0 kb | Distal (>10kb) Multiome | 432 | |
| chr15:55,688,707–55,689,258 | 190.7 kb | Distal (>10kb) Multiome | 82 | |
| chr15:55,741,161–55,743,756 | 244.9 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the DNAAF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.