This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CRMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:5,708,091–5,709,158 | 179.9 kb | Distal (>10kb) Multiome | 229 | |
| chr4:5,710,664–5,711,897 | 177.3 kb | Distal (>10kb) Multiome | 434 | |
| chr4:5,752,263–5,752,750 | 136.1 kb | Distal (>10kb) Multiome | 96 | |
| chr4:5,773,961–5,774,962 | 114.0 kb | Distal (>10kb) Multiome | 167 | |
| chr4:5,887,203–5,888,961 | 78 bp | At TSS Multiome | 278 | |
| chr4:5,889,712–5,890,892 | 1.8 kb | Proximal (<10kb) Multiome | 239 | |
| chr4:5,891,004–5,891,359 | 2.5 kb | Proximal (<10kb) | 141 | |
| chr4:5,892,257–5,893,532 | 4.7 kb | Proximal (<10kb) Multiome | 170 | |
| chr4:5,943,556–5,944,317 | 55.3 kb | Distal (>10kb) Multiome | 79 | |
| chr4:6,116,627–6,117,904 | 228.9 kb | Distal (>10kb) Multiome | 223 | |
| chr4:6,136,985–6,138,128 | 249.0 kb | Distal (>10kb) Multiome | 150 | |
| chr4:6,182,458–6,183,222 | 294.3 kb | Distal (>10kb) Multiome | 84 |
Genomic view of the CRMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.