This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for TMEM38B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM38B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM38B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:105,447,454–105,448,988 | 246.5 kb | Distal (>10kb) Multiome | 800 | |
| chr9:105,458,358–105,459,172 | 235.9 kb | Distal (>10kb) Multiome | 80 | |
| chr9:105,557,588–105,558,590 | 136.4 kb | Distal (>10kb) Multiome | 720 | |
| chr9:105,658,116–105,659,025 | 35.9 kb | Distal (>10kb) Multiome | 133 | |
| chr9:105,676,211–105,677,128 | 17.9 kb | Distal (>10kb) Multiome | 227 | |
| chr9:105,693,575–105,695,483 | 70 bp | At TSS Multiome | 751 | |
| chr9:105,975,902–105,976,967 | 281.9 kb | Distal (>10kb) Multiome | 162 | |
| chr9:107,190,398–107,191,484 | 1496.2 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr9:107,194,086–107,194,633 | 1499.9 kb | Distal (>10kb) Multiome HiCAR | 154 |
Genomic view of the TMEM38B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.