This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for LPIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,812,144–10,813,386 | 933.8 kb | Distal (>10kb) Multiome HiCAR | 759 | |
| chr2:11,465,452–11,466,561 | 280.5 kb | Distal (>10kb) Multiome | 1149 | |
| chr2:11,481,838–11,483,838 | 263.8 kb | Distal (>10kb) Multiome | 777 | |
| chr2:11,539,056–11,540,222 | 207.2 kb | Distal (>10kb) Multiome | 709 | |
| chr2:11,550,790–11,551,875 | 195.2 kb | Distal (>10kb) Multiome | 171 | |
| chr2:11,559,501–11,560,048 | 186.8 kb | Distal (>10kb) Multiome | 146 | |
| chr2:11,582,389–11,583,691 | 163.4 kb | Distal (>10kb) Multiome | 543 | |
| chr2:11,669,487–11,670,376 | 76.7 kb | Distal (>10kb) Multiome | 805 | |
| chr2:11,681,868–11,682,525 | 64.4 kb | Distal (>10kb) Multiome | 347 | |
| chr2:11,688,209–11,688,714 | 58.1 kb | Distal (>10kb) Multiome | 452 | |
| chr2:11,713,852–11,714,367 | 32.6 kb | Distal (>10kb) Multiome | 75 | |
| chr2:11,738,589–11,738,787 | 7.8 kb | Proximal (<10kb) | 265 | |
| chr2:11,743,889–11,745,399 | 2.4 kb | Proximal (<10kb) Multiome | 874 | |
| chr2:11,745,980–11,747,523 | 26 bp | At TSS Multiome | 809 | |
| chr2:11,747,890–11,748,315 | 1.3 kb | Proximal (<10kb) | 149 | |
| chr2:11,753,406–11,754,790 | 7.5 kb | Proximal (<10kb) Multiome HiCAR | 402 | |
| chr2:11,784,571–11,785,688 | 38.5 kb | Distal (>10kb) Multiome HiCAR | 317 | |
| chr2:11,829,052–11,830,741 | 83.5 kb | Distal (>10kb) Multiome | 941 | |
| chr2:11,863,504–11,864,327 | 117.3 kb | Distal (>10kb) Multiome | 541 |
Genomic view of the LPIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.