The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation This protein is involved in the formation and maintenance of dendritic spines, and modulates synaptic activity in neurons. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2019]
Transcription factors with Perturb-seq knockdown data for NCKIPSD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCKIPSD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCKIPSD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,428,528–48,430,504 | 255.9 kb | Distal (>10kb) Multiome | 910 | |
| chr3:48,439,801–48,440,548 | 245.7 kb | Distal (>10kb) Multiome | 787 | |
| chr3:48,446,396–48,447,180 | 239.2 kb | Distal (>10kb) Multiome | 767 | |
| chr3:48,465,344–48,466,310 | 220.2 kb | Distal (>10kb) Multiome | 670 | |
| chr3:48,472,636–48,473,658 | 212.7 kb | Distal (>10kb) Multiome | 821 | |
| chr3:48,503,451–48,504,839 | 181.8 kb | Distal (>10kb) Multiome | 419 | |
| chr3:48,556,022–48,557,666 | 128.9 kb | Distal (>10kb) Multiome | 794 | |
| chr3:48,558,131–48,558,793 | 127.5 kb | Distal (>10kb) Multiome | 503 | |
| chr3:48,608,816–48,610,628 | 76.3 kb | Distal (>10kb) Multiome | 850 | |
| chr3:48,634,696–48,636,251 | 50.3 kb | Distal (>10kb) Multiome | 898 | |
| chr3:48,655,787–48,657,257 | 29.5 kb | Distal (>10kb) Multiome | 438 | |
| chr3:48,661,275–48,664,636 | 24.2 kb | Distal (>10kb) Multiome | 1248 | |
| chr3:48,685,362–48,686,531 | 11 bp | At TSS Multiome | 770 | |
| chr3:48,695,430–48,695,683 | 9.5 kb | Proximal (<10kb) | 132 | |
| chr3:48,716,958–48,717,863 | 31.4 kb | Distal (>10kb) Multiome | 634 | |
| chr3:48,847,059–48,848,224 | 161.9 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr3:48,898,423–48,899,110 | 213.0 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 232.9 kb | Distal (>10kb) Multiome | 877 |
Genomic view of the NCKIPSD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.