Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; and regulation of mitochondrion organization. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHOT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:31,842,394–31,842,839 | 299.9 kb | Distal (>10kb) Multiome | 401 | |
| chr17:31,858,598–31,859,915 | 283.3 kb | Distal (>10kb) Multiome | 554 | |
| chr17:31,901,289–31,902,051 | 240.7 kb | Distal (>10kb) Multiome | 697 | |
| chr17:31,916,726–31,917,673 | 225.4 kb | Distal (>10kb) Multiome | 134 | |
| chr17:31,936,506–31,937,522 | 205.5 kb | Distal (>10kb) Multiome | 390 | |
| chr17:32,007,010–32,008,197 | 135.1 kb | Distal (>10kb) Multiome HiCAR | 620 | |
| chr17:32,120,048–32,120,809 | 22.1 kb | Distal (>10kb) Multiome | 65 | |
| chr17:32,127,304–32,127,868 | 15.0 kb | Distal (>10kb) Multiome | 369 | |
| chr17:32,138,967–32,139,169 | 3.4 kb | Proximal (<10kb) | 210 | |
| chr17:32,142,020–32,143,266 | 135 bp | At TSS Multiome | 737 | |
| chr17:32,265,505–32,266,972 | 123.1 kb | Distal (>10kb) Multiome | 354 | |
| chr17:32,341,667–32,342,507 | 199.5 kb | Distal (>10kb) Multiome | 954 | |
| chr17:32,349,923–32,350,604 | 207.6 kb | Distal (>10kb) Multiome | 814 |
Genomic view of the RHOT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.