The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ADAMTS7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,506,965–78,508,087 | 304.0 kb | Distal (>10kb) Multiome | 674 | |
| chr15:78,539,941–78,541,020 | 270.9 kb | Distal (>10kb) Multiome | 773 | |
| chr15:78,564,790–78,566,388 | 246.0 kb | Distal (>10kb) Multiome | 618 | |
| chr15:78,619,950–78,621,461 | 191.3 kb | Distal (>10kb) Multiome | 274 | |
| chr15:78,640,579–78,641,869 | 170.1 kb | Distal (>10kb) Multiome | 406 | |
| chr15:78,671,569–78,672,301 | 139.6 kb | Distal (>10kb) Multiome | 254 | |
| chr15:78,808,627–78,808,792 | 8.1 kb | Proximal (<10kb) | 74 | |
| chr15:78,810,245–78,812,147 | 75 bp | At TSS Multiome | 505 | |
| chr15:78,872,212–78,873,881 | 62.3 kb | Distal (>10kb) Multiome | 950 | |
| chr15:78,944,219–78,945,521 | 133.7 kb | Distal (>10kb) Multiome | 734 | |
| chr15:79,089,365–79,090,935 | 279.2 kb | Distal (>10kb) Multiome | 289 |
Genomic view of the ADAMTS7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.