The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for BIRC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BIRC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BIRC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:102,047,223–102,047,965 | 299.8 kb | Distal (>10kb) Multiome | 355 | |
| chr11:102,109,725–102,112,204 | 237.0 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:102,197,552–102,198,107 | 149.3 kb | Distal (>10kb) Multiome | 171 | |
| chr11:102,268,042–102,269,399 | 78.5 kb | Distal (>10kb) Multiome | 546 | |
| chr11:102,341,626–102,342,287 | 5.0 kb | Proximal (<10kb) | 444 | |
| chr11:102,346,630–102,348,333 | 62 bp | At TSS Multiome | 973 | |
| chr11:102,390,489–102,391,318 | 43.6 kb | Distal (>10kb) Multiome | 305 | |
| chr11:102,451,581–102,453,773 | 105.6 kb | Distal (>10kb) Multiome | 995 | |
| chr11:102,603,171–102,604,670 | 257.0 kb | Distal (>10kb) Multiome HiCAR | 319 | |
| chr11:102,612,813–102,613,765 | 266.0 kb | Distal (>10kb) Multiome HiCAR | 337 |
Genomic view of the BIRC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.