This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IFNGR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFNGR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFNGR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:136,920,717–136,924,225 | 295.7 kb | Distal (>10kb) Multiome | 498 | |
| chr6:136,956,824–136,957,720 | 262.2 kb | Distal (>10kb) Multiome | 256 | |
| chr6:136,989,383–136,990,306 | 229.6 kb | Distal (>10kb) Multiome | 295 | |
| chr6:137,001,359–137,002,211 | 217.5 kb | Distal (>10kb) Multiome | 208 | |
| chr6:137,044,029–137,045,166 | 174.8 kb | Distal (>10kb) Multiome | 428 | |
| chr6:137,218,440–137,220,020 | 39 bp | At TSS Multiome | 954 | |
| chr6:137,297,871–137,298,382 | 78.7 kb | Distal (>10kb) Multiome | 155 | |
| chr6:137,415,163–137,415,926 | 196.3 kb | Distal (>10kb) Multiome | 257 | |
| chr6:137,423,433–137,424,076 | 204.3 kb | Distal (>10kb) Multiome | 183 | |
| chr6:137,487,921–137,490,027 | 269.8 kb | Distal (>10kb) Multiome | 225 | |
| chr6:137,493,147–137,494,925 | 275.1 kb | Distal (>10kb) Multiome | 272 | |
| chr6:137,495,231–137,496,293 | 276.4 kb | Distal (>10kb) Multiome | 173 | |
| chr6:137,496,911–137,498,461 | 278.5 kb | Distal (>10kb) Multiome | 294 | |
| chr6:137,518,358–137,519,184 | 299.3 kb | Distal (>10kb) Multiome | 156 |
Genomic view of the IFNGR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.