This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for HPN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HPN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HPN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:34,772,709–34,773,413 | 268.6 kb | Distal (>10kb) Multiome | 680 | |
| chr19:34,920,040–34,921,057 | 121.2 kb | Distal (>10kb) Multiome | 309 | |
| chr19:34,926,731–34,927,343 | 114.8 kb | Distal (>10kb) Multiome | 741 | |
| chr19:34,963,909–34,964,414 | 77.6 kb | Distal (>10kb) Multiome | 645 | |
| chr19:34,999,304–35,000,970 | 41.5 kb | Distal (>10kb) Multiome | 759 | |
| chr19:35,030,124–35,031,270 | 11.2 kb | Distal (>10kb) Multiome | 534 | |
| chr19:35,040,969–35,041,953 | 162 bp | At TSS Multiome | 806 | |
| chr19:35,055,754–35,056,570 | 14.2 kb | Distal (>10kb) Multiome | 268 | |
| chr19:35,066,952–35,067,448 | 25.4 kb | Distal (>10kb) Multiome | 497 | |
| chr19:35,067,923–35,068,779 | 27.0 kb | Distal (>10kb) Multiome | 190 | |
| chr19:35,090,562–35,091,150 | 49.1 kb | Distal (>10kb) Multiome | 303 | |
| chr19:35,135,242–35,135,695 | 93.8 kb | Distal (>10kb) Multiome HiCAR | 525 | |
| chr19:35,140,763–35,141,948 | 99.6 kb | Distal (>10kb) Multiome | 509 | |
| chr19:35,142,085–35,143,541 | 101.3 kb | Distal (>10kb) Multiome | 328 | |
| chr19:35,154,641–35,155,298 | 113.4 kb | Distal (>10kb) Multiome | 552 | |
| chr19:35,247,580–35,249,688 | 207.0 kb | Distal (>10kb) Multiome | 1088 | |
| chr19:35,266,852–35,270,128 | 228.0 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the HPN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.