This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARID3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARID3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARID3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:632,653–633,806 | 292.2 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 286.0 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 262.5 kb | Distal (>10kb) Multiome | 723 | |
| chr19:679,616–681,731 | 245.1 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 221.8 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 217.0 kb | Distal (>10kb) Multiome | 317 | |
| chr19:796,668–798,362 | 128.6 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 103.6 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 63.6 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 32.6 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 8.0 kb | Proximal (<10kb) Multiome | 711 | |
| chr19:921,691–922,009 | 3.8 kb | Proximal (<10kb) | 500 | |
| chr19:924,743–926,242 | 85 bp | At TSS Multiome | 796 | |
| chr19:927,058–927,629 | 1.6 kb | Proximal (<10kb) Multiome | 362 | |
| chr19:982,565–983,215 | 57.0 kb | Distal (>10kb) Multiome HiCAR | 590 | |
| chr19:984,046–985,154 | 58.7 kb | Distal (>10kb) Multiome HiCAR | 829 | |
| chr19:1,000,142–1,000,881 | 74.6 kb | Distal (>10kb) Multiome | 399 | |
| chr19:1,020,611–1,022,069 | 95.6 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 100.7 kb | Distal (>10kb) Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 102.8 kb | Distal (>10kb) Multiome | 584 | |
| chr19:1,039,648–1,040,400 | 114.2 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 115.4 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 119.5 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 136.8 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 139.0 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 141.4 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 145.3 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 156.6 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 169.7 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 178.2 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 186.5 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 187.8 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 197.4 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 248.4 kb | Distal (>10kb) Multiome | 682 | |
| chr19:1,194,370–1,194,985 | 268.9 kb | Distal (>10kb) Multiome | 531 | |
| chr19:1,205,175–1,206,374 | 279.8 kb | Distal (>10kb) Multiome | 746 |
Genomic view of the ARID3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.