Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Located in mitochondrion and nucleoplasm. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CREBZF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREBZF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREBZF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:85,539,822–85,540,935 | 125.0 kb | Distal (>10kb) Multiome | 130 | |
| chr11:85,627,372–85,629,061 | 36.6 kb | Distal (>10kb) Multiome | 826 | |
| chr11:85,647,447–85,648,443 | 17.1 kb | Distal (>10kb) Multiome | 808 | |
| chr11:85,663,762–85,665,466 | 36 bp | At TSS Multiome | 999 | |
| chr11:85,809,696–85,811,885 | 146.1 kb | Distal (>10kb) Multiome | 535 | |
| chr11:85,854,605–85,855,812 | 190.0 kb | Distal (>10kb) Multiome | 948 | |
| chr11:86,244,135–86,246,099 | 579.9 kb | Distal (>10kb) Multiome HiCAR | 959 |
Genomic view of the CREBZF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.