Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOL4L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOL4L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOL4L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:32,189,679–32,190,832 | 293.2 kb | Distal (>10kb) Multiome | 290 | |
| chr20:32,207,261–32,208,118 | 275.7 kb | Distal (>10kb) Multiome | 903 | |
| chr20:32,277,439–32,278,095 | 205.9 kb | Distal (>10kb) Multiome | 804 | |
| chr20:32,357,509–32,359,534 | 124.2 kb | Distal (>10kb) Multiome | 1138 | |
| chr20:32,456,960–32,457,933 | 26.1 kb | Distal (>10kb) Multiome | 407 | |
| chr20:32,482,216–32,484,943 | 198 bp | At TSS Multiome | 976 | |
| chr20:32,485,083–32,485,450 | 1.6 kb | Proximal (<10kb) | 425 | |
| chr20:32,521,770–32,522,231 | 38.4 kb | Distal (>10kb) Multiome | 550 | |
| chr20:32,535,878–32,537,141 | 53.1 kb | Distal (>10kb) Multiome | 665 | |
| chr20:32,582,894–32,585,976 | 99.8 kb | Distal (>10kb) Multiome | 755 | |
| chr20:32,742,092–32,742,834 | 258.9 kb | Distal (>10kb) Multiome | 246 | |
| chr20:32,743,843–32,744,515 | 260.4 kb | Distal (>10kb) Multiome | 356 | |
| chr20:32,761,666–32,763,859 | 278.8 kb | Distal (>10kb) Multiome | 903 | |
| chr20:32,764,497–32,765,161 | 281.3 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the NOL4L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.