This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for SIRT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIRT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIRT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:67,763,355–67,765,388 | 120.3 kb | Distal (>10kb) Multiome | 1018 | |
| chr10:67,788,290–67,788,969 | 96.1 kb | Distal (>10kb) Multiome | 406 | |
| chr10:67,849,336–67,850,018 | 35.1 kb | Distal (>10kb) Multiome | 751 | |
| chr10:67,861,706–67,862,739 | 22.5 kb | Distal (>10kb) Multiome | 215 | |
| chr10:67,884,003–67,885,448 | 2 bp | At TSS Multiome | 1061 | |
| chr10:67,885,943–67,886,455 | 1.3 kb | Proximal (<10kb) | 64 | |
| chr10:68,074,303–68,075,534 | 190.5 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the SIRT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.