This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for SEC14L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC14L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC14L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,255,880–30,256,357 | 140.9 kb | Distal (>10kb) Multiome | 546 | |
| chr22:30,287,851–30,288,373 | 108.9 kb | Distal (>10kb) Multiome | 423 | |
| chr22:30,288,952–30,290,454 | 107.3 kb | Distal (>10kb) Multiome | 570 | |
| chr22:30,326,296–30,327,463 | 70.0 kb | Distal (>10kb) Multiome | 565 | |
| chr22:30,356,495–30,357,510 | 40.1 kb | Distal (>10kb) Multiome | 824 | |
| chr22:30,386,775–30,387,972 | 9.6 kb | Proximal (<10kb) Multiome | 499 | |
| chr22:30,391,189–30,391,400 | 5.6 kb | Proximal (<10kb) | 362 | |
| chr22:30,392,372–30,393,155 | 4.2 kb | Proximal (<10kb) Multiome | 209 | |
| chr22:30,396,849–30,397,353 | 6 bp | At TSS Multiome | 385 | |
| chr22:30,397,871–30,398,061 | 880 bp | At TSS | 74 | |
| chr22:30,422,945–30,424,825 | 27.1 kb | Distal (>10kb) Multiome | 1038 | |
| chr22:30,425,449–30,426,228 | 28.8 kb | Distal (>10kb) Multiome | 617 | |
| chr22:30,426,363–30,426,817 | 29.8 kb | Distal (>10kb) Multiome | 374 | |
| chr22:30,574,045–30,575,001 | 177.7 kb | Distal (>10kb) Multiome | 283 | |
| chr22:30,591,677–30,592,568 | 195.1 kb | Distal (>10kb) Multiome | 698 | |
| chr22:30,606,243–30,607,508 | 209.9 kb | Distal (>10kb) Multiome | 507 | |
| chr22:30,634,485–30,636,231 | 238.7 kb | Distal (>10kb) Multiome | 611 | |
| chr22:30,667,348–30,668,634 | 270.9 kb | Distal (>10kb) Multiome | 590 | |
| chr22:30,694,739–30,695,381 | 297.8 kb | Distal (>10kb) Multiome | 278 |
Genomic view of the SEC14L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.