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DE-5.22

Submodule 12 genes

RNA polymerase II transcriptional regulation

This 12-gene module includes SNX27, E2F5, KIF3B, ZNF268, and UBE2R2, and is enriched for RNA polymerase II cis-regulatory region sequence-specific DNA binding and cis-regulatory region sequence-specific DNA binding. No transcription factor knockdown data are available for this module, limiting inference of upstream regulatory control during ESC-to-DE differentiation.

Key terms: regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of DNA-templated transcription regulation of RNA biosynthetic process Notable genes: SNX27 E2F5 KIF3B ZNF268 UBE2R2 PITPNA ZNF274 GOLGA5

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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