This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TEAD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEAD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEAD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:2,691,016–2,691,920 | 267.7 kb | Distal (>10kb) Multiome | 194 | |
| chr12:2,752,645–2,753,234 | 206.5 kb | Distal (>10kb) Multiome | 945 | |
| chr12:2,794,243–2,796,266 | 163.3 kb | Distal (>10kb) Multiome | 802 | |
| chr12:2,812,386–2,813,317 | 146.7 kb | Distal (>10kb) Multiome | 1037 | |
| chr12:2,845,941–2,846,561 | 113.2 kb | Distal (>10kb) Multiome | 220 | |
| chr12:2,876,673–2,877,899 | 82.1 kb | Distal (>10kb) Multiome | 809 | |
| chr12:2,890,285–2,891,599 | 68.6 kb | Distal (>10kb) Multiome | 880 | |
| chr12:2,958,171–2,960,222 | 68 bp | At TSS Multiome | 770 | |
| chr12:2,963,897–2,964,194 | 4.5 kb | Proximal (<10kb) | 254 | |
| chr12:3,076,742–3,077,982 | 117.9 kb | Distal (>10kb) Multiome | 614 | |
| chr12:3,172,314–3,172,997 | 213.4 kb | Distal (>10kb) Multiome | 53 | |
| chr12:3,199,420–3,200,898 | 240.9 kb | Distal (>10kb) Multiome | 348 | |
| chr12:3,214,367–3,215,060 | 255.4 kb | Distal (>10kb) Multiome | 142 |
Genomic view of the TEAD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.