NFE2L2
NFE2 like bZIP transcription factor 2 | NRF-2, NRF2

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

Member of: DE-5
Biological processes 102 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)PERK-mediated unfolded protein response (GO:0036499)PERK-mediated unfolded protein response (GO:0036499)PERK-mediated unfolded protein response (GO:0036499)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)T cell differentiation (GO:0030217)aflatoxin catabolic process (GO:0046223)cell redox homeostasis (GO:0045454)cell redox homeostasis (GO:0045454)cellular response to angiotensin (GO:1904385)cellular response to fluid shear stress (GO:0071498)cellular response to glucose starvation (GO:0042149)cellular response to hydrogen peroxide (GO:0070301)cellular response to hydrogen peroxide (GO:0070301)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to laminar fluid shear stress (GO:0071499)cellular response to methionine (GO:0061431)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to tumor necrosis factor (GO:0071356)cellular response to tumor necrosis factor (GO:0071356)chromatin (GO:0000785)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum unfolded protein response (GO:0030968)integrated stress response signaling (GO:0140467)mediator complex (GO:0016592)molecular condensate scaffold activity (GO:0140693)negative regulation of cardiac muscle cell apoptotic process (GO:0010667)negative regulation of cellular response to hypoxia (GO:1900038)negative regulation of endothelial cell apoptotic process (GO:2000352)negative regulation of ferroptosis (GO:0110076)negative regulation of hematopoietic stem cell differentiation (GO:1902037)negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)negative regulation of vascular associated smooth muscle cell migration (GO:1904753)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of D-glucose import across plasma membrane (GO:0046326)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of ERAD pathway (GO:1904294)positive regulation of angiogenesis (GO:0045766)positive regulation of blood coagulation (GO:0030194)positive regulation of blood vessel endothelial cell migration (GO:0043536)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of glutathione biosynthetic process (GO:1903788)positive regulation of neuron projection development (GO:0010976)positive regulation of reactive oxygen species metabolic process (GO:2000379)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)proteasomal ubiquitin-independent protein catabolic process (GO:0010499)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein ubiquitination (GO:0016567)protein-DNA complex (GO:0032993)protein-DNA complex (GO:0032993)regulation of DNA-templated transcription (GO:0006355)regulation of cellular response to oxidative stress (GO:1900407)regulation of innate immune response (GO:0045088)regulation of innate immune response (GO:0045088)regulation of removal of superoxide radicals (GO:2000121)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to endoplasmic reticulum stress (GO:0034976)response to ischemia (GO:0002931)response to oxidative stress (GO:0006979)response to xenobiotic stimulus (GO:0009410)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription coregulator binding (GO:0001221)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
NFE2L2 — as a Regulated Gene

TFs regulating NFE2L2 0 TFs

Transcription factors with Perturb-seq knockdown data for NFE2L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFE2L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NFE2L2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFE2L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:177,024,602–177,025,177 367.8 kb Distal (>10kb) Multiome 113
chr2:177,211,967–177,213,482 180.1 kb Distal (>10kb) Multiome 1144
chr2:177,254,514–177,254,739 8.8 kb Proximal (<10kb) 253
chr2:177,263,465–177,265,584 127.8 kb Distal (>10kb) Multiome 1275
chr2:177,284,272–177,285,351 108.0 kb Distal (>10kb) Multiome 132
chr2:177,310,707–177,311,501 81.6 kb Distal (>10kb) Multiome 84
chr2:177,392,346–177,393,257 52 bp At TSS Multiome 1012
chr2:177,394,330–177,394,724 1.6 kb Proximal (<10kb) 214
chr2:177,478,776–177,479,348 86.4 kb Distal (>10kb) Multiome 41
chr2:177,535,764–177,536,624 143.5 kb Distal (>10kb) Multiome 160
chr2:177,552,350–177,553,389 160.2 kb Distal (>10kb) Multiome 825
chr2:177,618,280–177,619,321 226.1 kb Distal (>10kb) Multiome 849
chr2:177,681,932–177,682,409 289.4 kb Distal (>10kb) Multiome 64

Genome Browser

Genomic view of the NFE2L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:177,014,602 – 177,692,409
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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