This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for ADGRG6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRG6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRG6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:142,014,564–142,016,190 | 286.7 kb | Distal (>10kb) Multiome | 335 | |
| chr6:142,146,802–142,147,679 | 154.6 kb | Distal (>10kb) Multiome | 1022 | |
| chr6:142,232,181–142,233,204 | 69.2 kb | Distal (>10kb) Multiome | 349 | |
| chr6:142,300,903–142,303,069 | 47 bp | At TSS Multiome | 950 | |
| chr6:142,306,383–142,307,286 | 4.5 kb | Proximal (<10kb) | 96 |
Genomic view of the ADGRG6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.