The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KIF3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:32,017,795–32,019,711 | 259.3 kb | Distal (>10kb) Multiome | 611 | |
| chr20:32,031,048–32,031,781 | 246.1 kb | Distal (>10kb) Multiome | 627 | |
| chr20:32,109,321–32,110,237 | 167.9 kb | Distal (>10kb) Multiome | 1073 | |
| chr20:32,189,679–32,190,832 | 87.3 kb | Distal (>10kb) Multiome | 290 | |
| chr20:32,207,261–32,208,118 | 69.9 kb | Distal (>10kb) Multiome | 903 | |
| chr20:32,277,439–32,278,095 | 20 bp | At TSS Multiome | 804 | |
| chr20:32,357,509–32,359,534 | 81.7 kb | Distal (>10kb) Multiome | 1138 | |
| chr20:32,456,960–32,457,933 | 179.8 kb | Distal (>10kb) Multiome | 407 | |
| chr20:32,482,216–32,484,943 | 206.0 kb | Distal (>10kb) Multiome | 976 | |
| chr20:32,521,770–32,522,231 | 244.3 kb | Distal (>10kb) Multiome | 550 | |
| chr20:32,535,878–32,537,141 | 259.0 kb | Distal (>10kb) Multiome | 665 |
Genomic view of the KIF3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.