The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for SLC35A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:87,322,367–87,323,025 | 150.4 kb | Distal (>10kb) Multiome | 892 | |
| chr6:87,407,486–87,408,928 | 64.7 kb | Distal (>10kb) Multiome | 735 | |
| chr6:87,472,409–87,473,809 | 139 bp | At TSS Multiome | 913 | |
| chr6:87,483,840–87,484,329 | 11.3 kb | Distal (>10kb) Multiome | 125 | |
| chr6:87,551,523–87,552,511 | 78.9 kb | Distal (>10kb) Multiome | 64 | |
| chr6:87,589,655–87,590,489 | 117.1 kb | Distal (>10kb) Multiome | 803 | |
| chr6:87,700,848–87,703,142 | 229.5 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the SLC35A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.