IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IRF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:184,343,497–184,344,121 | 130.6 kb | Distal (>10kb) Multiome | 417 | |
| chr4:184,347,285–184,347,920 | 127.0 kb | Distal (>10kb) Multiome | 359 | |
| chr4:184,472,503–184,475,460 | 215 bp | At TSS Multiome | 965 | |
| chr4:184,536,785–184,538,298 | 63.1 kb | Distal (>10kb) Multiome | 704 | |
| chr4:184,625,573–184,626,654 | 151.7 kb | Distal (>10kb) Multiome | 388 | |
| chr4:184,648,062–184,650,476 | 175.0 kb | Distal (>10kb) Multiome | 822 | |
| chr4:184,733,143–184,734,876 | 259.7 kb | Distal (>10kb) Multiome | 1145 |
Genomic view of the IRF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.