ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for MAP9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:154,548,823–154,550,849 | 826.4 kb | Distal (>10kb) Multiome HiCAR | 633 | |
| chr4:154,626,265–154,627,724 | 749.9 kb | Distal (>10kb) Multiome HiCAR | 532 | |
| chr4:155,207,400–155,209,247 | 168.2 kb | Distal (>10kb) Multiome | 341 | |
| chr4:155,371,588–155,371,753 | 5.1 kb | Proximal (<10kb) | 30 | |
| chr4:155,376,323–155,377,313 | 18 bp | At TSS Multiome | 467 | |
| chr4:155,383,492–155,384,644 | 6.7 kb | Proximal (<10kb) | 113 | |
| chr4:155,535,346–155,536,931 | 159.1 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the MAP9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.