TNPO2

transportin 2 | FLJ12155, IPO3, KPNB2B, TRN2

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. Implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.24

Biological processes 14 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)intracellular protein transport (GO:0006886)nuclear import signal receptor activity (GO:0061608)nuclear localization sequence binding (GO:0008139)nuclear localization sequence binding (GO:0008139)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein import into nucleus (GO:0006606)protein import into nucleus (GO:0006606)small GTPase binding (GO:0031267)

Expression (TPM)

TFs regulating TNPO2 0 TFs

Transcription factors with Perturb-seq knockdown data for TNPO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNPO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TNPO2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNPO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,440,217–12,441,483	282.9 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	239.1 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	228.5 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	172.4 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	152.2 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	113.0 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	83.7 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	76.2 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	66.8 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	57.2 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	54.4 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	42.5 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	27.3 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	20.7 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	1.5 kb	Proximal (<10kb) Multiome	807
chr19:12,723,726–12,724,142	147 bp	At TSS Multiome	539
chr19:12,734,221–12,735,284	10.8 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	13.2 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	33.9 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	42.3 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	51.5 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	54.0 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	58.8 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	66.1 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	67.6 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	69.8 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	78.0 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	82.6 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	101.9 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	108.7 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	110.0 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	114.5 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	116.9 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	123.8 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	143.7 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	149.4 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	157.6 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	161.5 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	167.1 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	189.4 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	195.5 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	209.8 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	214.5 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	222.0 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	233.3 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	241.5 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	259.7 kb	Distal (>10kb) Multiome	688

Genome Browser

Genomic view of the TNPO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.