Predicted to enable adenyl-nucleotide exchange factor activity. Involved in chaperone-mediated protein complex assembly and protein insertion into mitochondrial outer membrane. Located in cytosol and extracellular exosome. Implicated in Chagas disease. Biomarker of chronic obstructive pulmonary disease; rheumatoid arthritis; type 2 diabetes mellitus; and ulcerative colitis. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for HSPA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:132,776,389–132,777,915 | 274.7 kb | Distal (>10kb) Multiome | 587 | |
| chr5:132,813,194–132,815,033 | 237.4 kb | Distal (>10kb) Multiome | 418 | |
| chr5:132,822,729–132,823,756 | 228.8 kb | Distal (>10kb) Multiome | 258 | |
| chr5:132,825,176–132,826,484 | 226.3 kb | Distal (>10kb) Multiome | 208 | |
| chr5:132,829,647–132,831,156 | 221.7 kb | Distal (>10kb) Multiome | 877 | |
| chr5:132,866,046–132,867,186 | 185.5 kb | Distal (>10kb) Multiome | 955 | |
| chr5:132,963,042–132,964,332 | 88.3 kb | Distal (>10kb) Multiome HiCAR | 1068 | |
| chr5:133,026,009–133,027,021 | 25.4 kb | Distal (>10kb) Multiome | 754 | |
| chr5:133,050,485–133,050,753 | 1.3 kb | Proximal (<10kb) | 98 | |
| chr5:133,051,201–133,052,938 | 117 bp | At TSS Multiome | 1018 |
Genomic view of the HSPA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.