This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for DEAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:406,008–408,661 | 288.0 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 277.9 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 247.0 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 245.0 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 188.1 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 159.6 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 157.8 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 140.1 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 134.4 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 126.6 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 119.1 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 81.5 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 79.3 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 58.1 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 222 bp | At TSS Multiome | 873 | |
| chr11:705,737–706,270 | 10.8 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 25.7 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 32.9 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 52.1 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 68.1 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 82.2 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 88.5 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 103.0 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 110.1 kb | Distal (>10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 114.5 kb | Distal (>10kb) Multiome | 976 | |
| chr11:818,369–820,592 | 124.3 kb | Distal (>10kb) Multiome | 749 | |
| chr11:826,980–828,116 | 132.3 kb | Distal (>10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 135.2 kb | Distal (>10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 137.6 kb | Distal (>10kb) Multiome | 562 | |
| chr11:842,034–843,556 | 147.5 kb | Distal (>10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 149.2 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 154.6 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 215.7 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 230.6 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the DEAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.