Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCAR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCAR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCAR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,471,473–68,472,528 | 249.3 kb | Distal (>10kb) Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 193.7 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,559,963–68,561,065 | 160.8 kb | Distal (>10kb) Multiome | 777 | |
| chr10:68,600,036–68,600,760 | 120.8 kb | Distal (>10kb) Multiome | 755 | |
| chr10:68,720,659–68,721,908 | 39 bp | At TSS Multiome | 939 | |
| chr10:68,826,917–68,827,679 | 106.1 kb | Distal (>10kb) Multiome | 577 | |
| chr10:68,900,541–68,901,785 | 180.0 kb | Distal (>10kb) Multiome | 1082 | |
| chr10:68,955,769–68,956,761 | 235.0 kb | Distal (>10kb) Multiome | 938 | |
| chr10:68,988,361–68,989,558 | 267.6 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the CCAR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.