This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for RNF170. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF170 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF170, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:42,692,358–42,693,015 | 204.6 kb | Distal (>10kb) Multiome | 396 | |
| chr8:42,831,245–42,833,658 | 65.6 kb | Distal (>10kb) Multiome | 84 | |
| chr8:42,842,552–42,843,812 | 54.1 kb | Distal (>10kb) Multiome | 969 | |
| chr8:42,893,597–42,893,975 | 2.7 kb | Proximal (<10kb) | 141 | |
| chr8:42,894,257–42,894,399 | 2.3 kb | Proximal (<10kb) | 218 | |
| chr8:42,895,783–42,897,989 | 581 bp | At TSS Multiome | 792 | |
| chr8:43,055,656–43,057,748 | 159.0 kb | Distal (>10kb) Multiome | 1003 | |
| chr8:43,092,366–43,094,313 | 196.3 kb | Distal (>10kb) Multiome | 903 | |
| chr8:43,138,945–43,139,610 | 241.9 kb | Distal (>10kb) Multiome | 219 | |
| chr8:43,139,728–43,142,039 | 244.3 kb | Distal (>10kb) Multiome | 861 |
Genomic view of the RNF170 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.