Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of protein kinase activity. Located in cytosol; fibrillar center; and nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MLLT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLLT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLLT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,110,281–6,110,936 | 169.3 kb | Distal (>10kb) Multiome | 518 | |
| chr19:6,199,134–6,200,121 | 80.3 kb | Distal (>10kb) Multiome | 769 | |
| chr19:6,279,539–6,280,376 | 119 bp | At TSS Multiome | 761 | |
| chr19:6,361,350–6,362,018 | 81.6 kb | Distal (>10kb) Multiome | 803 | |
| chr19:6,372,272–6,374,427 | 93.5 kb | Distal (>10kb) Multiome | 925 | |
| chr19:6,392,902–6,394,077 | 113.5 kb | Distal (>10kb) Multiome | 767 | |
| chr19:6,423,613–6,425,899 | 145.2 kb | Distal (>10kb) Multiome | 956 | |
| chr19:6,458,960–6,460,940 | 180.4 kb | Distal (>10kb) Multiome | 859 | |
| chr19:6,463,863–6,464,838 | 184.3 kb | Distal (>10kb) Multiome | 526 | |
| chr19:6,470,903–6,471,589 | 191.3 kb | Distal (>10kb) Multiome | 26 | |
| chr19:6,475,386–6,477,353 | 196.6 kb | Distal (>10kb) Multiome | 419 | |
| chr19:6,515,952–6,517,331 | 236.2 kb | Distal (>10kb) Multiome | 732 | |
| chr19:6,530,842–6,531,584 | 251.0 kb | Distal (>10kb) Multiome | 640 | |
| chr19:6,551,766–6,552,224 | 272.1 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the MLLT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.