Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COX15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:99,519,844–99,520,769 | 211.8 kb | Distal (>10kb) Multiome | 331 | |
| chr10:99,522,567–99,524,013 | 208.8 kb | Distal (>10kb) Multiome | 201 | |
| chr10:99,527,131–99,527,911 | 204.6 kb | Distal (>10kb) Multiome | 89 | |
| chr10:99,532,575–99,533,287 | 199.2 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,534,863–99,536,063 | 196.7 kb | Distal (>10kb) Multiome | 193 | |
| chr10:99,536,574–99,538,002 | 195.0 kb | Distal (>10kb) Multiome | 279 | |
| chr10:99,619,825–99,621,725 | 111.4 kb | Distal (>10kb) Multiome | 1070 | |
| chr10:99,658,847–99,660,052 | 72.7 kb | Distal (>10kb) Multiome | 728 | |
| chr10:99,731,799–99,732,929 | 174 bp | At TSS Multiome | 941 | |
| chr10:99,913,671–99,914,615 | 182.0 kb | Distal (>10kb) Multiome | 256 | |
| chr10:100,009,381–100,010,564 | 277.8 kb | Distal (>10kb) Multiome | 647 |
Genomic view of the COX15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.